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Title | Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover. |
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Journal, issue, pages | Biochemistry, Vol. 56, Page 4951-4961, Year 2017 |
Publish date | May 22, 2017 (structure data deposition date) |
Authors | Mascarenhas, R. / Le, H.V. / Clevenger, K.D. / Lehrer, H.J. / Ringe, D. / Kelleher, N.L. / Silverman, R.B. / Liu, D. |
External links | Biochemistry / PubMed:28816437 |
Methods | X-ray diffraction |
Resolution | 1.72 - 1.8 Å |
Structure data | PDB-5vwo: PDB-5vwq: PDB-5vwr: |
Chemicals | ChemComp-9QJ: ChemComp-HOH: ChemComp-PMP: ChemComp-PL6: ChemComp-GOL: |
Source |
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Keywords | TRANSFERASE / Aminotransferase / Mechanism-based inactivator / PLP / Aspartate aminotransferase / PMP / (1R / 3S / 4S)-3-amino-4-fluorocyclopentane-1-carboxylic acid (FCP) / ketimine / alpha-ketoglutarate |