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| Title | Identification of a Potent, Selective, and Efficacious Phosphatidylinositol 3-Kinase delta (PI3K delta ) Inhibitor for the Treatment of Immunological Disorders. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 60, Page 5193-5208, Year 2017 |
| Publish date | Apr 26, 2017 (structure data deposition date) |
 Authors | Liu, Q. / Shi, Q. / Marcoux, D. / Batt, D.G. / Cornelius, L. / Qin, L.Y. / Ruan, Z. / Neels, J. / Beaudoin-Bertrand, M. / Srivastava, A.S. ...Liu, Q. / Shi, Q. / Marcoux, D. / Batt, D.G. / Cornelius, L. / Qin, L.Y. / Ruan, Z. / Neels, J. / Beaudoin-Bertrand, M. / Srivastava, A.S. / Li, L. / Cherney, R.J. / Gong, H. / Watterson, S.H. / Weigelt, C. / Gillooly, K.M. / McIntyre, K.W. / Xie, J.H. / Obermeier, M.T. / Fura, A. / Sleczka, B. / Stefanski, K. / Fancher, R.M. / Padmanabhan, S. / Rp, T. / Kundu, I. / Rajareddy, K. / Smith, R. / Hennan, J.K. / Xing, D. / Fan, J. / Levesque, P.C. / Ruan, Q. / Pitt, S. / Zhang, R. / Pedicord, D. / Pan, J. / Yarde, M. / Lu, H. / Lippy, J. / Goldstine, C. / Skala, S. / Rampulla, R.A. / Mathur, A. / Gupta, A. / Arunachalam, P.N. / Sack, J.S. / Muckelbauer, J.K. / Cvijic, M.E. / Salter-Cid, L.M. / Bhide, R.S. / Poss, M.A. / Hynes, J. / Carter, P.H. / Macor, J.E. / Ruepp, S. / Schieven, G.L. / Tino, J.A. |
 External links | J. Med. Chem. / PubMed:28541707 |
| Methods | X-ray diffraction |
| Resolution | 2.8 Å |
| Structure data |  PDB-5vlr: |
| Chemicals |  ChemComp-9EM:  ChemComp-HOH: |
| Source |
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 Keywords | TRANSFERASE/TRANSFERASE REGULATOR / LIPID KINASE / INHIBITOR / PI3K DELTA / TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX / TRANSFERASE-TRANSFERASE REGULATOR complex |
homo sapiens (human)