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-Structure paper
Title | Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity. |
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Journal, issue, pages | J. Med. Chem., Vol. 58, Page 2180-2194, Year 2015 |
Publish date | Apr 21, 2017 (structure data deposition date) |
Authors | Bruncko, M. / Wang, L. / Sheppard, G.S. / Phillips, D.C. / Tahir, S.K. / Xue, J. / Erickson, S. / Fidanze, S. / Fry, E. / Hasvold, L. ...Bruncko, M. / Wang, L. / Sheppard, G.S. / Phillips, D.C. / Tahir, S.K. / Xue, J. / Erickson, S. / Fidanze, S. / Fry, E. / Hasvold, L. / Jenkins, G.J. / Jin, S. / Judge, R.A. / Kovar, P.J. / Madar, D. / Nimmer, P. / Park, C. / Petros, A.M. / Rosenberg, S.H. / Smith, M.L. / Song, X. / Sun, C. / Tao, Z.F. / Wang, X. / Xiao, Y. / Zhang, H. / Tse, C. / Leverson, J.D. / Elmore, S.W. / Souers, A.J. |
External links | J. Med. Chem. / PubMed:25679114 |
Methods | X-ray diffraction |
Resolution | 1.95 - 2.31 Å |
Structure data | PDB-5vkc: PDB-6b4l: PDB-6b4u: |
Chemicals | ChemComp-9EA: ChemComp-ZN: ChemComp-HOH: ChemComp-CJY: ChemComp-CN7: |
Source |
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Keywords | signaling protein/inhibitor / MCL-1 / signaling protein-inhibitor complex / SIGNALING PROTEIN |