Database of articles cited by EMDB/PDB/SASBDB data

Keywords
Structure methods	All X-ray diffraction NMR electron microscopy small angle scattering neutron diffraction fiber diffraction powder diffraction infrared spectroscopy EPR fluorescence transfer theoretical model Hybrid
Author
Journal
IF	>30 >20 >10 >5 all

Title	Rational approach to highly potent and selective apoptosis signal-regulating kinase 1 (ASK1) inhibitors.
Journal, issue, pages	Eur J Med Chem, Vol. 145, Page 606-621, Year 2017
Publish date	Apr 17, 2017 (structure data deposition date)
Authors	Lovering, F. / Morgan, P. / Allais, C. / Aulabaugh, A. / Brodfuehrer, J. / Chang, J. / Coe, J. / Ding, W. / Dowty, H. / Fleming, M. ...Lovering, F. / Morgan, P. / Allais, C. / Aulabaugh, A. / Brodfuehrer, J. / Chang, J. / Coe, J. / Ding, W. / Dowty, H. / Fleming, M. / Frisbie, R. / Guzova, J. / Hepworth, D. / Jasti, J. / Kortum, S. / Kurumbail, R. / Mohan, S. / Papaioannou, N. / Strohbach, J.W. / Vincent, F. / Lee, K. / Zapf, C.W.
External links	Eur J Med Chem / PubMed:29348070
Methods	X-ray diffraction
Resolution	2.64 - 2.84 Å
Structure data	PDB-5vil: Crystal structure of ASK1 kinase domain with a potent inhibitor (analog 6) Method: X-RAY DIFFRACTION / Resolution: 2.64 Å PDB-5vio: Crystal structure of ASK1 kinase domain with a potent inhibitor (analog 13) Method: X-RAY DIFFRACTION / Resolution: 2.84 Å
Chemicals	ChemComp-9E1: 2-methoxy-N-{6-[4-(propan-2-yl)-4H-1,2,4-triazol-3-yl]pyridin-2-yl}-5-sulfamoylbenzamide ChemComp-DMS: DIMETHYL SULFOXIDE / DMSO, precipitantYM ChemComp-HOH: WATER ChemComp-9E4*: 4-methoxy-N~1~-methyl-N~3~-{6-[4-(propan-2-yl)-4H-1,2,4-triazol-3-yl]pyridin-2-yl}benzene-1,3-dicarboxamide
Source	homo sapiens (human)
Keywords	TRANSFERASE/TRANSFERASE INHIBITOR / kinase drug discovery / TRANSFERASE-TRANSFERASE INHIBITOR complex / ASK1