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-Structure paper
Title | Discovery of Potent and Selective Tricyclic Inhibitors of Bruton's Tyrosine Kinase with Improved Druglike Properties. |
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Journal, issue, pages | ACS Med Chem Lett, Vol. 8, Page 608-613, Year 2017 |
Publish date | Apr 11, 2017 (structure data deposition date) |
Authors | Wang, X. / Barbosa, J. / Blomgren, P. / Bremer, M.C. / Chen, J. / Crawford, J.J. / Deng, W. / Dong, L. / Eigenbrot, C. / Gallion, S. ...Wang, X. / Barbosa, J. / Blomgren, P. / Bremer, M.C. / Chen, J. / Crawford, J.J. / Deng, W. / Dong, L. / Eigenbrot, C. / Gallion, S. / Hau, J. / Hu, H. / Johnson, A.R. / Katewa, A. / Kropf, J.E. / Lee, S.H. / Liu, L. / Lubach, J.W. / Macaluso, J. / Maciejewski, P. / Mitchell, S.A. / Ortwine, D.F. / DiPaolo, J. / Reif, K. / Scheerens, H. / Schmitt, A. / Wong, H. / Xiong, J.M. / Xu, J. / Zhao, Z. / Zhou, F. / Currie, K.S. / Young, W.B. |
External links | ACS Med Chem Lett / PubMed:28626519 |
Methods | X-ray diffraction |
Resolution | 1.621 Å |
Structure data | PDB-5vgo: |
Chemicals | ChemComp-SO4: ChemComp-GOL: ChemComp-PG0: ChemComp-9B1: ChemComp-HOH: |
Source |
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Keywords | Transferase/Transferase Inhibitor / protein kinase / inhibitor / Transferase-Transferase Inhibitor complex |