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Title | ETX2514 is a broad-spectrum beta-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii. |
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Journal, issue, pages | Nat Microbiol, Vol. 2, Page 17104-17104, Year 2017 |
Publish date | Apr 7, 2017 (structure data deposition date) |
![]() | Durand-Reville, T.F. / Guler, S. / Comita-Prevoir, J. / Chen, B. / Bifulco, N. / Huynh, H. / Lahiri, S. / Shapiro, A.B. / McLeod, S.M. / Carter, N.M. ...Durand-Reville, T.F. / Guler, S. / Comita-Prevoir, J. / Chen, B. / Bifulco, N. / Huynh, H. / Lahiri, S. / Shapiro, A.B. / McLeod, S.M. / Carter, N.M. / Moussa, S.H. / Velez-Vega, C. / Olivier, N.B. / McLaughlin, R. / Gao, N. / Thresher, J. / Palmer, T. / Andrews, B. / Giacobbe, R.A. / Newman, J.V. / Ehmann, D.E. / de Jonge, B. / O'Donnell, J. / Mueller, J.P. / Tommasi, R.A. / Miller, A.A. |
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Methods | X-ray diffraction |
Resolution | 1.93 Å |
Structure data | ![]() PDB-5vfd: |
Chemicals | ![]() ChemComp-SO4: ![]() ChemComp-9CP: ![]() ChemComp-9CM: ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE/HYDROLASE INHIBITOR / ETX2514 / beta-lactamase / PBP Gram negative / Astrazeneca / Entasis / A. baumannii / covalent inhibitor / HYDROLASE-HYDROLASE INHIBITOR complex |