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Structure paper

TitleCrystal Structures of Human GlyR alpha 3 Bound to Ivermectin.
Journal, issue, pagesStructure, Vol. 25, Page 945-950.e2, Year 2017
Publish dateApr 3, 2017 (structure data deposition date)
AuthorsHuang, X. / Chen, H. / Shaffer, P.L.
External linksStructure / PubMed:28479061
MethodsX-ray diffraction
Resolution2.85 - 3.1 Å
Structure data

PDB-5vdh:
Crystal Structure of Human Glycine Receptor alpha-3 Bound to AM-3607, Glycine, and Ivermectin
Method: X-RAY DIFFRACTION / Resolution: 2.85 Å

PDB-5vdi:
Crystal Structure of Human Glycine Receptor alpha-3 Mutant N38Q Bound to AM-3607, Glycine, and Ivermectin
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Chemicals

ChemComp-7C6:
(3S,3aS,9bS)-2-[(2H-1,3-benzodioxol-5-yl)sulfonyl]-3,5-dimethyl-1,2,3,3a,5,9b-hexahydro-4H-pyrrolo[3,4-c][1,6]naphthyridin-4-one

ChemComp-GLY:
GLYCINE

ChemComp-IVM:
(2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 / medication, antiparasitic*YM

ChemComp-ZN:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSPORT PROTEIN / Ligand-gated Ion Channel / Neurotransmitter Receptor / Membrane Protein / Cys-loop receptor

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