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TitleFunctional analysis of human cytochrome P450 21A2 variants involved in congenital adrenal hyperplasia.
Journal, issue, pagesJ. Biol. Chem., Vol. 292, Page 10767-10778, Year 2017
Publish dateMar 30, 2017 (structure data deposition date)
AuthorsWang, C. / Pallan, P.S. / Zhang, W. / Lei, L. / Yoshimoto, F.K. / Waterman, M.R. / Egli, M. / Guengerich, F.P.
External linksJ. Biol. Chem. / PubMed:28539365
MethodsX-ray diffraction
Resolution3.31 Å
Structure data

PDB-5vbu:
Crystal Structure of Human Cytochrome P450 21A2 Hydroxyprogesterone Complex
Method: X-RAY DIFFRACTION / Resolution: 3.31 Å

Chemicals

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

ChemComp-3QZ:
(9beta)-17-hydroxypregn-4-ene-3,20-dione / hormone*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / STEROID HYDROXYLATION / MONOOXYGENASES / ADRENAL STEROIDOGENESIS / CONGENITAL ADRENAL HYPERPLASIA / ADDISON'S DISEASE / KINETIC ISOTOPE EFFECTS / Hydroxyprogesterone

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