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| Title | Design and Discovery of N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 60, Page 4869-4881, Year 2017 |
| Publish date | Mar 27, 2017 (structure data deposition date) |
 Authors | Nishiguchi, G.A. / Rico, A. / Tanner, H. / Aversa, R.J. / Taft, B.R. / Subramanian, S. / Setti, L. / Burger, M.T. / Wan, L. / Tamez, V. ...Nishiguchi, G.A. / Rico, A. / Tanner, H. / Aversa, R.J. / Taft, B.R. / Subramanian, S. / Setti, L. / Burger, M.T. / Wan, L. / Tamez, V. / Smith, A. / Lou, Y. / Barsanti, P.A. / Appleton, B.A. / Mamo, M. / Tandeske, L. / Dix, I. / Tellew, J.E. / Huang, S. / Mathews Griner, L.A. / Cooke, V.G. / Van Abbema, A. / Merritt, H. / Ma, S. / Gampa, K. / Feng, F. / Yuan, J. / Wang, Y. / Haling, J.R. / Vaziri, S. / Hekmat-Nejad, M. / Jansen, J.M. / Polyakov, V. / Zang, R. / Sethuraman, V. / Amiri, P. / Singh, M. / Lees, E. / Shao, W. / Stuart, D.D. / Dillon, M.P. / Ramurthy, S. |
 External links | J. Med. Chem. / PubMed:28557458 |
| Methods | X-ray diffraction |
| Resolution | 2.1 - 2.26 Å |
| Structure data |  PDB-5val:  PDB-5vam: |
| Chemicals |  ChemComp-92D:  ChemComp-HOH:  ChemComp-92J: |
| Source |
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 Keywords | TRANSFERASE/TRANSFERASE inhibitor / BRAF Serine/threonine-protein kinase B-raf / TRANSFERASE-TRANSFERASE inhibitor complex |
homo sapiens (human)