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-Structure paper
Title | KRAS G12C Drug Development: Discrimination between Switch II Pocket Configurations Using Hydrogen/Deuterium-Exchange Mass Spectrometry. |
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Journal, issue, pages | Structure, Vol. 25, Page 1442-1448.e3, Year 2017 |
Publish date | Mar 17, 2017 (structure data deposition date) |
![]() | Lu, J. / Harrison, R.A. / Li, L. / Zeng, M. / Gondi, S. / Scott, D. / Gray, N.S. / Engen, J.R. / Westover, K.D. |
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Methods | X-ray diffraction |
Resolution | 2.228 Å |
Structure data | ![]() PDB-5v71: |
Chemicals | ![]() ChemComp-GDP: ![]() ChemComp-MG: ![]() ChemComp-8ZG: ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE/HYDROLASE inhibitor / KRAS / covalent inhibitor / quinazoline based / HYDROLASE-HYDROLASE inhibitor complex |