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TitleA common antagonistic mechanism for class A GPCRs revealed by the structure of the human 5-HT1B serotonin receptor bound to an antagonist
Journal, issue, pagesCell Discov, Year 2018
Publish dateMar 13, 2017 (structure data deposition date)
AuthorsYin, W.C. / Zhou, X.E. / Yang, D. / De Waal, P. / Wang, M.T. / Dai, A. / Cai, X. / Huang, C.Y. / Liu, P. / Yin, Y. ...Yin, W.C. / Zhou, X.E. / Yang, D. / De Waal, P. / Wang, M.T. / Dai, A. / Cai, X. / Huang, C.Y. / Liu, P. / Yin, Y. / Liu, B. / Caffrey, M. / Melcher, K. / Xu, Y. / Wang, M.W. / Xu, H.E. / Jiang, Y.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution3.9 Å
Structure data

PDB-5v54:
Crystal structure of 5-HT1B receptor in complex with methiothepin
Method: X-RAY DIFFRACTION / Resolution: 3.9 Å

Chemicals

ChemComp-89F:
1-methyl-4-[(5~{S})-3-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-5-yl]piperazine / antipsychotic, antagonist*YM

Source
  • homo sapiens (human)
  • spodoptera frugiperda (fall armyworm)
KeywordsELECTRON TRANSPORT / 5-hydroxytryptamine / GPCR antagonist / OB1

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