+Search query
-Structure paper
Title | Optimization of a binding fragment targeting the "enlarged methionine pocket" leads to potent Trypanosoma brucei methionyl-tRNA synthetase inhibitors. |
---|---|
Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 27, Page 2702-2707, Year 2017 |
Publish date | Mar 8, 2017 (structure data deposition date) |
![]() | Huang, W. / Zhang, Z. / Ranade, R.M. / Gillespie, J.R. / Barros-Alvarez, X. / Creason, S.A. / Shibata, S. / Verlinde, C.L.M.J. / Hol, W.G.J. / Buckner, F.S. / Fan, E. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 2.3 Å |
Structure data | ![]() PDB-5v49: |
Chemicals | ![]() ChemComp-MET: ![]() ChemComp-8WA: ![]() ChemComp-GOL: ![]() ChemComp-HOH: |
Source |
|
![]() | Ligase/Ligase Inhibitor / synthetase / ligase / methionine / inhibitor / Ligase-Ligase Inhibitor complex |