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-Structure paper
Title | A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos. |
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Journal, issue, pages | J. Med. Chem., Vol. 61, Page 535-542, Year 2018 |
Publish date | Mar 7, 2017 (structure data deposition date) |
Authors | Matyskiela, M.E. / Zhang, W. / Man, H.W. / Muller, G. / Khambatta, G. / Baculi, F. / Hickman, M. / LeBrun, L. / Pagarigan, B. / Carmel, G. ...Matyskiela, M.E. / Zhang, W. / Man, H.W. / Muller, G. / Khambatta, G. / Baculi, F. / Hickman, M. / LeBrun, L. / Pagarigan, B. / Carmel, G. / Lu, C.C. / Lu, G. / Riley, M. / Satoh, Y. / Schafer, P. / Daniel, T.O. / Carmichael, J. / Cathers, B.E. / Chamberlain, P.P. |
External links | J. Med. Chem. / PubMed:28425720 |
Methods | X-ray diffraction |
Resolution | 3.2 Å |
Structure data | PDB-5v3o: |
Chemicals | ChemComp-8W7: ChemComp-ZN: |
Source |
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Keywords | LIGASE / E3 / ubiquitin ligase / CRL4 / DCAF |