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-Structure paper
Title | Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1. |
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Journal, issue, pages | Elife, Vol. 6, Year 2017 |
Publish date | Feb 17, 2017 (structure data deposition date) |
![]() | Jenson, J.M. / Ryan, J.A. / Grant, R.A. / Letai, A. / Keating, A.E. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 1.199 - 2.346 Å |
Structure data | ![]() PDB-5uuk: ![]() PDB-5uul: ![]() PDB-5uum: ![]() PDB-5uup: |
Chemicals | ![]() ChemComp-SO4: ![]() ChemComp-HOH: ![]() ChemComp-ZN: |
Source |
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![]() | APOPTOSIS / Apoptosis Regulatory Proteins / Peptide Library / Protein Binding / Protein Structure / Proto-Oncogene / Specificity / BCL2A1 / BCL2 related protein A1 / Peptide Inhibitor / Electrophile |