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Structure paper

TitleUnsaturated fatty acyl recognition by Frizzled receptors mediates dimerization upon Wnt ligand binding.
Journal, issue, pagesProc. Natl. Acad. Sci. U.S.A., Vol. 114, Page 4147-4152, Year 2017
Publish dateAug 29, 2016 (structure data deposition date)
AuthorsNile, A.H. / Mukund, S. / Stanger, K. / Wang, W. / Hannoush, R.N.
External linksProc. Natl. Acad. Sci. U.S.A. / PubMed:28377511
MethodsX-ray diffraction
Resolution1.9944 - 2.202 Å
Structure data

PDB-5t44:
Crystal structure of Frizzled 7 CRD
Method: X-RAY DIFFRACTION / Resolution: 1.9944 Å

PDB-5urv:
Crystal structure of Frizzled 7 CRD in complex with C24 fatty acid
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-5ury:
Crystal structure of Frizzled 5 CRD in complex with PAM
Method: X-RAY DIFFRACTION / Resolution: 2.098 Å

PDB-5urz:
Crystal structure of Frizzled 5 CRD in complex with BOG
Method: X-RAY DIFFRACTION / Resolution: 2.202 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-NER:
(15E)-TETRACOS-15-ENOIC ACID

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-SO4:
SULFATE ION

ChemComp-1PG:
2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL

ChemComp-PAM:
PALMITOLEIC ACID

ChemComp-BOG:
octyl beta-D-glucopyranoside / detergent*YM

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Cysteine rich domain / Frizzled 7 / CRD / SIGNALING PROTEIN / Frizzled 5

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