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Title | Design and Development of Highly Potent HIV-1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants. |
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Journal, issue, pages | J. Med. Chem., Vol. 60, Page 4267-4278, Year 2017 |
Publish date | Jan 25, 2017 (structure data deposition date) |
![]() | Ghosh, A.K. / Rao, K.V. / Nyalapatla, P.R. / Osswald, H.L. / Martyr, C.D. / Aoki, M. / Hayashi, H. / Agniswamy, J. / Wang, Y.F. / Bulut, H. ...Ghosh, A.K. / Rao, K.V. / Nyalapatla, P.R. / Osswald, H.L. / Martyr, C.D. / Aoki, M. / Hayashi, H. / Agniswamy, J. / Wang, Y.F. / Bulut, H. / Das, D. / Weber, I.T. / Mitsuya, H. |
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Methods | X-ray diffraction |
Resolution | 1.53 Å |
Structure data | ![]() PDB-5ult: |
Chemicals | ![]() ChemComp-NA: ![]() ChemComp-CL: ![]() ChemComp-8FM: ![]() ChemComp-HOH: |
Source |
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![]() | hydrolase/hydrolase inhibitor / Crown-like Oxotricyclic Core / HIV-1 protease inhibitor GRL-100-13A / darunavir / multidrug-resistant / hydrolase inhibitor complex / hydrolase-hydrolase inhibitor complex |