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TitleA human antibody against Zika virus crosslinks the E protein to prevent infection.
Journal, issue, pagesNat Commun, Vol. 8, Page 14722, Year 2017
Publish dateMar 16, 2017
AuthorsS Saif Hasan / Andrew Miller / Gopal Sapparapu / Estefania Fernandez / Thomas Klose / Feng Long / Andrei Fokine / Jason C Porta / Wen Jiang / Michael S Diamond / James E Crowe / Richard J Kuhn / Michael G Rossmann /
PubMed AbstractThe recent Zika virus (ZIKV) epidemic has been linked to unusual and severe clinical manifestations including microcephaly in fetuses of infected pregnant women and Guillian-Barré syndrome in adults. ...The recent Zika virus (ZIKV) epidemic has been linked to unusual and severe clinical manifestations including microcephaly in fetuses of infected pregnant women and Guillian-Barré syndrome in adults. Neutralizing antibodies present a possible therapeutic approach to prevent and control ZIKV infection. Here we present a 6.2 Å resolution three-dimensional cryo-electron microscopy (cryoEM) structure of an infectious ZIKV (strain H/PF/2013, French Polynesia) in complex with the Fab fragment of a highly therapeutic and neutralizing human monoclonal antibody, ZIKV-117. The antibody had been shown to prevent fetal infection and demise in mice. The structure shows that ZIKV-117 Fabs cross-link the monomers within the surface E glycoprotein dimers as well as between neighbouring dimers, thus preventing the reorganization of E protein monomers into fusogenic trimers in the acidic environment of endosomes.
External linksNat Commun / PubMed:28300075 / PubMed Central
MethodsEM (single particle)
Resolution6.2 Å
Structure data

8548

5uhy

EMDB-8548, PDB-5uhy:
A Human Antibody Against Zika Virus Crosslinks the E Protein to Prevent Infection
Method: EM (single particle) / Resolution: 6.2 Å

Source
  • zika virus
  • homo sapiens (human)
KeywordsVIRUS/IMMUNE SYSTEM / flavivirus / Zika / human antibody / therapeutic / VIRUS-IMMUNE SYSTEM complex

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