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Structure paper

TitleMET Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of an HGF Antibody.
Journal, issue, pagesMol. Cancer Ther., Vol. 16, Page 1269-1278, Year 2017
Publish dateDec 19, 2016 (structure data deposition date)
AuthorsFarrell, P.J. / Matuszkiewicz, J. / Balakrishna, D. / Pandya, S. / Hixon, M.S. / Kamran, R. / Chu, S. / Lawson, J.D. / Okada, K. / Hori, A. ...Farrell, P.J. / Matuszkiewicz, J. / Balakrishna, D. / Pandya, S. / Hixon, M.S. / Kamran, R. / Chu, S. / Lawson, J.D. / Okada, K. / Hori, A. / Mizutani, A. / Iwata, H. / de Jong, R. / Hibner, B. / Vincent, P.
External linksMol. Cancer Ther. / PubMed:28341789
MethodsX-ray diffraction
Resolution1.9 - 2.25 Å
Structure data

PDB-5uab:
MET Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of an HGF Antibody
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-5uad:
MET Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of an HGF Antibody
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

PDB-6ubw:
MET Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of an HGF Antibody
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-84M:
N-{6-[([1,2,4]triazolo[4,3-a]pyridin-3-yl)sulfanyl]imidazo[1,2-b]pyridazin-2-yl}cyclopropanecarboxamide

ChemComp-GOL:
GLYCEROL

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-84P:
N-(6-{[6-(1-methyl-1H-pyrazol-4-yl)-1H-benzotriazol-1-yl]methyl}imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide

ChemComp-84S:
N-(6-{difluoro[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]methyl}imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/INHIBITOR / MET / Tyrosine Kinase / Inhibitor / Antitumor / TRANSFERASE-INHIBITOR complex / TRANSFERASE-TRANSFERASE INHIBITOR / TRANSFERASE-TRANSFERASE INHIBITOR complex

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