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-Structure paper
Title | Dual-activity PI3K-BRD4 inhibitor for the orthogonal inhibition of MYC to block tumor growth and metastasis. |
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Journal, issue, pages | Proc. Natl. Acad. Sci. U.S.A., Vol. 114, Page E1072-E1080, Year 2017 |
Publish date | Nov 30, 2016 (structure data deposition date) |
Authors | Andrews, F.H. / Singh, A.R. / Joshi, S. / Smith, C.A. / Morales, G.A. / Garlich, J.R. / Durden, D.L. / Kutateladze, T.G. |
External links | Proc. Natl. Acad. Sci. U.S.A. / PubMed:28137841 |
Methods | X-ray diffraction |
Resolution | 1.798 - 3.3 Å |
Structure data | PDB-5u28: PDB-5u2c: PDB-5u2e: PDB-5u2f: |
Chemicals | ChemComp-82V: ChemComp-PEG: ChemComp-SCN: ChemComp-HOH: ChemComp-82Y: ChemComp-837: |
Source |
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Keywords | TRANSCRIPTION REGULATOR/INHIBITOR / bromodomain / transcription / inhibitor / epigenetics / TRANSCRIPTION REGULATOR-INHIBITOR complex |