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Title | Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40. |
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Journal, issue, pages | Nat. Struct. Mol. Biol., Vol. 24, Page 570-577, Year 2017 |
Publish date | Nov 22, 2016 (structure data deposition date) |
Authors | Lu, J. / Byrne, N. / Wang, J. / Bricogne, G. / Brown, F.K. / Chobanian, H.R. / Colletti, S.L. / Di Salvo, J. / Thomas-Fowlkes, B. / Guo, Y. ...Lu, J. / Byrne, N. / Wang, J. / Bricogne, G. / Brown, F.K. / Chobanian, H.R. / Colletti, S.L. / Di Salvo, J. / Thomas-Fowlkes, B. / Guo, Y. / Hall, D.L. / Hadix, J. / Hastings, N.B. / Hermes, J.D. / Ho, T. / Howard, A.D. / Josien, H. / Kornienko, M. / Lumb, K.J. / Miller, M.W. / Patel, S.B. / Pio, B. / Plummer, C.W. / Sherborne, B.S. / Sheth, P. / Souza, S. / Tummala, S. / Vonrhein, C. / Webb, M. / Allen, S.J. / Johnston, J.M. / Weinglass, A.B. / Sharma, S. / Soisson, S.M. |
External links | Nat. Struct. Mol. Biol. / PubMed:28581512 |
Methods | X-ray diffraction |
Resolution | 2.2 - 3.22 Å |
Structure data | PDB-5tzr: PDB-5tzy: |
Chemicals | ChemComp-NA: ChemComp-MK6: ChemComp-MLI: ChemComp-OLC: ChemComp-1PE: ChemComp-HOH: ChemComp-7OS: |
Source |
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Keywords | FATTY ACID BINDING PROTEIN/HYDROLASE / FFAR1 / partial agonist / FATTY ACID BINDING PROTEIN-HYDROLASE complex |