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Structure paper

TitleMELK is not necessary for the proliferation of basal-like breast cancer cells.
Journal, issue, pagesElife, Vol. 6, Year 2017
Publish dateNov 14, 2016 (structure data deposition date)
AuthorsHuang, H.T. / Seo, H.S. / Zhang, T. / Wang, Y. / Jiang, B. / Li, Q. / Buckley, D.L. / Nabet, B. / Roberts, J.M. / Paulk, J. ...Huang, H.T. / Seo, H.S. / Zhang, T. / Wang, Y. / Jiang, B. / Li, Q. / Buckley, D.L. / Nabet, B. / Roberts, J.M. / Paulk, J. / Dastjerdi, S. / Winter, G.E. / McLauchlan, H. / Moran, J. / Bradner, J.E. / Eck, M.J. / Dhe-Paganon, S. / Zhao, J.J. / Gray, N.S.
External linksElife / PubMed:28926338
MethodsX-ray diffraction
Resolution2.42 - 2.91 Å
Structure data

PDB-5twl:
Structure of Maternal Embryonic Leucine Zipper Kinase
Method: X-RAY DIFFRACTION / Resolution: 2.42 Å

PDB-5twu:
Structure of Maternal Embryonic Leucine Zipper Kinase
Method: X-RAY DIFFRACTION / Resolution: 2.603 Å

PDB-5twy:
Structure of Maternal Embryonic Leucine Zipper Kinase
Method: X-RAY DIFFRACTION / Resolution: 2.91 Å

PDB-5twz:
Structure of Maternal Embryonic Leucine Zipper Kinase
Method: X-RAY DIFFRACTION / Resolution: 2.631 Å

PDB-5tx3:
Structure of Maternal Embryonic Leucine Zipper Kinase
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-H91:
9-(3,5-dichloro-4-hydroxyphenyl)-1-{trans-4-[(dimethylamino)methyl]cyclohexyl}-3,4-dihydropyrimido[5,4-c]quinolin-2(1H)-one

ChemComp-HOH:
WATER

ChemComp-7LY:
2-(benzyloxy)-4-(1H-pyrazol-4-yl)-N-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)benzamide

ChemComp-45R:
7-{[2-methoxy-4-(1H-pyrazol-4-yl)benzoyl]amino}-2,3,4,5-tetrahydro-1H-3-benzazepinium

ChemComp-7MY:
7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethyl-2-({3-[(pyrrolidin-1-yl)methyl]phenyl}amino)-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

Source
  • homo sapiens (human)
KeywordsTransferase/Transferase Inhibitor / kinase inhibitor / basal-like breast cancer / Transferase-Transferase Inhibitor complex / TRANSFERASE / kinase / inhibitor / breast cancer

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