+Search query
-Structure paper
Title | Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans. |
---|---|
Journal, issue, pages | J. Med. Chem., Vol. 60, Page 1971-1993, Year 2017 |
Publish date | Nov 4, 2016 (structure data deposition date) |
Authors | Thorarensen, A. / Dowty, M.E. / Banker, M.E. / Juba, B. / Jussif, J. / Lin, T. / Vincent, F. / Czerwinski, R.M. / Casimiro-Garcia, A. / Unwalla, R. ...Thorarensen, A. / Dowty, M.E. / Banker, M.E. / Juba, B. / Jussif, J. / Lin, T. / Vincent, F. / Czerwinski, R.M. / Casimiro-Garcia, A. / Unwalla, R. / Trujillo, J.I. / Liang, S. / Balbo, P. / Che, Y. / Gilbert, A.M. / Brown, M.F. / Hayward, M. / Montgomery, J. / Leung, L. / Yang, X. / Soucy, S. / Hegen, M. / Coe, J. / Langille, J. / Vajdos, F. / Chrencik, J. / Telliez, J.B. |
External links | J. Med. Chem. / PubMed:28139931 |
Methods | X-ray diffraction |
Resolution | 1.72 - 2.34 Å |
Structure data | PDB-5tts: PDB-5ttu: PDB-5ttv: |
Chemicals | ChemComp-7KU: ChemComp-HOH: ChemComp-7KV: ChemComp-SO4: ChemComp-7KX: |
Source |
|
Keywords | TRANSFERASE/TRANSFERASE inhibitor / kinase / covalent / TRANSFERASE-TRANSFERASE inhibitor complex |