Database of articles cited by EMDB/PDB/SASBDB data

Keywords
Structure methods	All X-ray diffraction NMR electron microscopy small angle scattering neutron diffraction fiber diffraction powder diffraction infrared spectroscopy EPR fluorescence transfer theoretical model Hybrid
Author
Journal
IF	>30 >20 >10 >5 all

Title	Discovery of TAK-659 an orally available investigational inhibitor of Spleen Tyrosine Kinase (SYK).
Journal, issue, pages	Bioorg. Med. Chem. Lett., Vol. 26, Page 5947-5950, Year 2016
Publish date	Oct 25, 2016 (structure data deposition date)
Authors	Lam, B. / Arikawa, Y. / Cramlett, J. / Dong, Q. / de Jong, R. / Feher, V. / Grimshaw, C.E. / Farrell, P.J. / Hoffman, I.D. / Jennings, A. ...Lam, B. / Arikawa, Y. / Cramlett, J. / Dong, Q. / de Jong, R. / Feher, V. / Grimshaw, C.E. / Farrell, P.J. / Hoffman, I.D. / Jennings, A. / Jones, B. / Matuszkiewicz, J. / Miura, J. / Miyake, H. / Natala, S.R. / Shi, L. / Takahashi, M. / Taylor, E. / Wyrick, C. / Yano, J. / Zalevsky, J. / Nie, Z.
External links	Bioorg. Med. Chem. Lett. / PubMed:27839918
Methods	X-ray diffraction
Resolution	1.77 - 1.93 Å
Structure data	PDB-5tr6: Discovery of TAK-659, an Orally Available Investigational Inhibitor of Spleen Tyrosine Kinase (SYK) Method: X-RAY DIFFRACTION / Resolution: 1.93 Å PDB-5tt7: Discovery of TAK-659, an Orally Available Investigational Inhibitor of Spleen Tyrosine Kinase (SYK) Method: X-RAY DIFFRACTION / Resolution: 1.77 Å
Chemicals	ChemComp-7KG: 6-{[(1R,2S)-2-aminocyclohexyl]amino}-7-fluoro-4-(1-methyl-1H-pyrazol-4-yl)-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one ChemComp-EDO: 1,2-ETHANEDIOL ChemComp-HOH: WATER ChemComp-7KF: 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-5-one
Source	homo sapiens (human)
Keywords	Transferase/Transferase Inhibitor / Inhibitor / kinase / Leukemia / Lymphoma / Transferase-Transferase Inhibitor complex