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Structure paper

TitleSAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression.
Journal, issue, pagesCancer Res., Vol. 74, Page 5855-5865, Year 2014
Publish dateOct 26, 2016 (structure data deposition date)
AuthorsWang, S. / Sun, W. / Zhao, Y. / McEachern, D. / Meaux, I. / Barriere, C. / Stuckey, J.A. / Meagher, J.L. / Bai, L. / Liu, L. ...Wang, S. / Sun, W. / Zhao, Y. / McEachern, D. / Meaux, I. / Barriere, C. / Stuckey, J.A. / Meagher, J.L. / Bai, L. / Liu, L. / Hoffman-Luca, C.G. / Lu, J. / Shangary, S. / Yu, S. / Bernard, D. / Aguilar, A. / Dos-Santos, O. / Besret, L. / Guerif, S. / Pannier, P. / Gorge-Bernat, D. / Debussche, L.
External linksCancer Res. / PubMed:25145672
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-5trf:
MDM2 in complex with SAR405838
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-7HC:
(2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-N-(trans-4-hydroxycyclohexyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsLIGASE/LIGASE INHIBITOR / P53-BINDING PROTEIN / ONCOPROTEIN / DOUBLE MINUTE 2 PROTEIN / SMALL MOLECULE INHIBITOR / LIGASE-LIGASE INHIBITOR complex

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