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-Structure paper
Title | Discovery of TAK-659 an orally available investigational inhibitor of Spleen Tyrosine Kinase (SYK). |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 26, Page 5947-5950, Year 2016 |
Publish date | Oct 25, 2016 (structure data deposition date) |
Authors | Lam, B. / Arikawa, Y. / Cramlett, J. / Dong, Q. / de Jong, R. / Feher, V. / Grimshaw, C.E. / Farrell, P.J. / Hoffman, I.D. / Jennings, A. ...Lam, B. / Arikawa, Y. / Cramlett, J. / Dong, Q. / de Jong, R. / Feher, V. / Grimshaw, C.E. / Farrell, P.J. / Hoffman, I.D. / Jennings, A. / Jones, B. / Matuszkiewicz, J. / Miura, J. / Miyake, H. / Natala, S.R. / Shi, L. / Takahashi, M. / Taylor, E. / Wyrick, C. / Yano, J. / Zalevsky, J. / Nie, Z. |
External links | Bioorg. Med. Chem. Lett. / PubMed:27839918 |
Methods | X-ray diffraction |
Resolution | 1.77 - 1.93 Å |
Structure data | PDB-5tr6: PDB-5tt7: |
Chemicals | ChemComp-7KG: ChemComp-EDO: ChemComp-HOH: ChemComp-7KF: |
Source |
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Keywords | Transferase/Transferase Inhibitor / Inhibitor / kinase / Leukemia / Lymphoma / Transferase-Transferase Inhibitor complex |