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| Title | Identification of imidazo[1,2-b]pyridazine TYK2 pseudokinase ligands as potent and selective allosteric inhibitors of TYK2 signalling. |
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| Journal, issue, pages | Medchemcomm, Vol. 8, Page 700-712, Year 2017 |
| Publish date | Oct 6, 2016 (structure data deposition date) |
 Authors | Moslin, R. / Gardner, D. / Santella, J. / Zhang, Y. / Duncia, J.V. / Liu, C. / Lin, J. / Tokarski, J.S. / Strnad, J. / Pedicord, D. ...Moslin, R. / Gardner, D. / Santella, J. / Zhang, Y. / Duncia, J.V. / Liu, C. / Lin, J. / Tokarski, J.S. / Strnad, J. / Pedicord, D. / Chen, J. / Blat, Y. / Zupa-Fernandez, A. / Cheng, L. / Sun, H. / Chaudhry, C. / Huang, C. / D'Arienzo, C. / Sack, J.S. / Muckelbauer, J.K. / Chang, C. / Tredup, J. / Xie, D. / Aranibar, N. / Burke, J.R. / Carter, P.H. / Weinstein, D.S. |
 External links | Medchemcomm / PubMed:30108788 |
| Methods | X-ray diffraction |
| Resolution | 1.92 - 2.16 Å |
| Structure data |  PDB-5tkb:  PDB-5tkd: |
| Chemicals |  ChemComp-ZN:  ChemComp-MG:  ChemComp-SO4:  ChemComp-EOH:  ChemComp-7DJ:  ChemComp-HOH:  ChemComp-7GL: |
| Source |
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 Keywords | HYDROLASE/HYDROLASE inhibitor / PHOSPHODIESTERASE / PDE4D / ALTERNATIVE SPLICING / CAMP / CYTOPLASM / CYTOSKELETON / HYDROLASE / MEMBRANE / METAL- BINDING / PHOSPHOPROTEIN / HYDROLASE-HYDROLASE inhibitor complex / TRANSFERASE / KINASE / TYK2 / PSEUDOKINASE |
homo sapiens (human)