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TitleCrystal Structures of Human GlyRa3 Bound to a Novel Class of Potentiators with Efficacy in a Mouse Model of Neuropathic Pain
Journal, issue, pagesTo Be Published
Publish dateOct 3, 2016 (structure data deposition date)
AuthorsHuang, X. / Shaffer, P.L. / Ayube, S. / Bregman, H. / Chen, H. / Lehto, S.G. / Luther, J.A. / Matson, D.J. / McDonough, S.I. / Michelsen, K. ...Huang, X. / Shaffer, P.L. / Ayube, S. / Bregman, H. / Chen, H. / Lehto, S.G. / Luther, J.A. / Matson, D.J. / McDonough, S.I. / Michelsen, K. / Plant, M.M. / Schneider, S. / Simard, J.R. / Teffera, Y. / Yi, S. / Zhang, M. / DiMauro, E.F. / Gingras, J.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.61 - 3.25 Å
Structure data

PDB-5tin:
Crystal Structure of Human Glycine Receptor alpha-3 Mutant N38Q Bound to AM-3607
Method: X-RAY DIFFRACTION / Resolution: 2.61 Å

PDB-5tio:
Crystal Structure of Human Glycine Receptor alpha-3 Bound to AM-3607
Method: X-RAY DIFFRACTION / Resolution: 3.25 Å

Chemicals

ChemComp-7C6:
(3S,3aS,9bS)-2-[(2H-1,3-benzodioxol-5-yl)sulfonyl]-3,5-dimethyl-1,2,3,3a,5,9b-hexahydro-4H-pyrrolo[3,4-c][1,6]naphthyridin-4-one

ChemComp-GLY:
GLYCINE

ChemComp-ZN:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
KeywordsTRANSPORT PROTEIN / LIGAND-GATED ION CHANNEL NEUROTRANSMITTER RECEPTOR MEMBRANE PROTEIN CYS-LOOP RECEPTOR

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