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TitleCrystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor.
Journal, issue, pagesCancer Res., Vol. 77, Page 937-948, Year 2017
Publish dateSep 14, 2016 (structure data deposition date)
AuthorsGustafsson, R. / Jemth, A.S. / Gustafsson, N.M. / Farnegardh, K. / Loseva, O. / Wiita, E. / Bonagas, N. / Dahllund, L. / Llona-Minguez, S. / Haggblad, M. ...Gustafsson, R. / Jemth, A.S. / Gustafsson, N.M. / Farnegardh, K. / Loseva, O. / Wiita, E. / Bonagas, N. / Dahllund, L. / Llona-Minguez, S. / Haggblad, M. / Henriksson, M. / Andersson, Y. / Homan, E. / Helleday, T. / Stenmark, P.
External linksCancer Res. / PubMed:27899380
MethodsX-ray diffraction
Resolution1.89 Å
Structure data

PDB-5tc4:
Crystal structure of human mitochondrial methylenetetrahydrofolate dehydrogenase-cyclohydrolase (MTHFD2) in complex with LY345899 and cofactors
Method: X-RAY DIFFRACTION / Resolution: 1.89 Å

Chemicals

ChemComp-NAD:
NICOTINAMIDE-ADENINE-DINUCLEOTIDE / NAD*YM

ChemComp-L34:
4-(7-AMINO-9-HYDROXY-1-OXO-3,3A,4,5-TETRAHYDRO-2,5,6,8,9B-PENTAAZA-CYCLOPENTA[A]NAPHTHALEN-2-YL)-PHENYLCARBONYL-GLUTAMI

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / Inhibitor / Folate / Cofactor / Dehydrogenase

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