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-Structure paper
Title | Structure-based optimization of 1H-imidazole-2-carboxamides as Axl kinase inhibitors utilizing a Mer mutant surrogate. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 27, Page 1099-1104, Year 2017 |
Publish date | Sep 13, 2016 (structure data deposition date) |
Authors | Keung, W. / Boloor, A. / Brown, J. / Kiryanov, A. / Gangloff, A. / Lawson, J.D. / Skene, R. / Hoffman, I. / Atienza, J. / Kahana, J. ...Keung, W. / Boloor, A. / Brown, J. / Kiryanov, A. / Gangloff, A. / Lawson, J.D. / Skene, R. / Hoffman, I. / Atienza, J. / Kahana, J. / De Jong, R. / Farrell, P. / Balakrishna, D. / Halkowycz, P. |
External links | Bioorg. Med. Chem. Lett. / PubMed:28082036 |
Methods | X-ray diffraction |
Resolution | 2.24 - 2.68 Å |
Structure data | PDB-5tc0: PDB-5td2: |
Chemicals | ChemComp-79Y: ChemComp-HOH: ChemComp-7AE: |
Source |
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Keywords | Transferase/Transferase Inhibitor / kinase / inhibitor / surrogate / oncology / Transferase-Transferase Inhibitor complex |