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TitleSynthesis and optimization of furano[3,2-d]pyrimidines as selective spleen tyrosine kinase (Syk) inhibitors.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 26, Page 5562-5567, Year 2016
Publish dateSep 1, 2016 (structure data deposition date)
AuthorsHoemann, M. / Wilson, N. / Argiriadi, M. / Banach, D. / Burchat, A. / Calderwood, D. / Clapham, B. / Cox, P. / Duignan, D.B. / Konopacki, D. ...Hoemann, M. / Wilson, N. / Argiriadi, M. / Banach, D. / Burchat, A. / Calderwood, D. / Clapham, B. / Cox, P. / Duignan, D.B. / Konopacki, D. / Somal, G. / Vasudevan, A.
External linksBioorg. Med. Chem. Lett. / PubMed:27789138
MethodsX-ray diffraction
Resolution2.93 Å
Structure data

PDB-5t68:
Crystal structure of Syk catalytic domain in complex with a furo[3,2-d]pyrimidine
Method: X-RAY DIFFRACTION / Resolution: 2.93 Å

Chemicals

ChemComp-77V:
N~4~-cyclopropyl-N~2~-(3-methyl-1H-indazol-6-yl)furo[3,2-d]pyrimidine-2,4-diamine

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTransferase/Transferase Inhibitor / Spleen Tyrosine Kinase Syk catalytic domain / Transferase-Transferase Inhibitor complex

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