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TitleA fluorinated indole-based MDM2 antagonist selectively inhibits the growth of p53wtosteosarcoma cells.
Journal, issue, pagesFebs J., Vol. 286, Page 1360-1374, Year 2019
Publish dateJun 22, 2017 (structure data deposition date)
AuthorsSkalniak, L. / Twarda-Clapa, A. / Neochoritis, C.G. / Surmiak, E. / Machula, M. / Wisniewska, A. / Labuzek, B. / Ali, A.M. / Krzanik, S. / Dubin, G. ...Skalniak, L. / Twarda-Clapa, A. / Neochoritis, C.G. / Surmiak, E. / Machula, M. / Wisniewska, A. / Labuzek, B. / Ali, A.M. / Krzanik, S. / Dubin, G. / Groves, M. / Domling, A. / Holak, T.A.
External linksFebs J. / PubMed:30715803
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-5oai:
Structure of MDM2 with low molecular weight inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-B5K:
3-[(1~{R})-2-(~{tert}-butylamino)-1-[methanoyl-[[3,4,5-tris(fluoranyl)phenyl]methyl]amino]-2-oxidanylidene-ethyl]-6-chloranyl-1~{H}-indole-2-carboxylic acid

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsLIGASE / p53 / MDM2 / MDMX / protein-protein interaction / cancer / inhibitor

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