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TitleUnbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade.
Journal, issue, pagesCancer Cell, Vol. 33, Page 922-936.e10, Year 2018
Publish dateMay 29, 2017 (structure data deposition date)
AuthorsGeuijen, C.A.W. / De Nardis, C. / Maussang, D. / Rovers, E. / Gallenne, T. / Hendriks, L.J.A. / Visser, T. / Nijhuis, R. / Logtenberg, T. / de Kruif, J. ...Geuijen, C.A.W. / De Nardis, C. / Maussang, D. / Rovers, E. / Gallenne, T. / Hendriks, L.J.A. / Visser, T. / Nijhuis, R. / Logtenberg, T. / de Kruif, J. / Gros, P. / Throsby, M.
External linksCancer Cell / PubMed:29763625
MethodsX-ray diffraction
Resolution3 - 4.5 Å
Structure data

PDB-5o4g:
HER2 in complex with Fab MF3958
Method: X-RAY DIFFRACTION / Resolution: 3 Å

PDB-5o4o:
HER3 in complex with Fab MF3178
Method: X-RAY DIFFRACTION / Resolution: 3.4 Å

PDB-5o7p:
HER3 in complex with Fab MF3178
Method: X-RAY DIFFRACTION / Resolution: 4.5 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
KeywordsONCOPROTEIN / HER2 ectodomain / complex / Fab / transferase / IMMUNE SYSTEM / HER3 ectodomain

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