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Structure paper

TitleQuinolin-6-Yloxyacetamides Are Microtubule Destabilizing Agents That Bind to the Colchicine Site of Tubulin.
Journal, issue, pagesInt J Mol Sci, Vol. 18, Year 2017
Publish dateJun 8, 2017 (structure data deposition date)
AuthorsSharma, A. / Saez-Calvo, G. / Olieric, N. / de Asis Balaguer, F. / Barasoain, I. / Lamberth, C. / Diaz, J.F. / Steinmetz, M.O.
External linksInt J Mol Sci / PubMed:28640209
MethodsX-ray diffraction
Resolution2.495 Å
Structure data

PDB-5o7a:
Quinolin-6-yloxyacetamides are microtubule destabilizing agents that bind to the colchicine site of tubulin
Method: X-RAY DIFFRACTION / Resolution: 2.495 Å

Chemicals

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-9N5:
(2~{R})-2-(3-ethynylquinolin-6-yl)oxy-2-methoxy-~{N}-[(1~{E})-1-methoxyimino-2-methyl-propan-2-yl]ethanamide

ChemComp-ACP:
PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER / AMP-PCP, energy-carrying molecule analogue*YM

ChemComp-HOH:
WATER

Source
  • rattus norvegicus (Norway rat)
  • gallus gallus (chicken)
  • bos taurus (domestic cattle)
KeywordsMOTOR PROTEIN / Microtubules / Tubulin / Colchicine / Quinolin-6-yloxyacetamides

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