EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Structure-based discovery of selective BRPF1 bromodomain inhibitors.
ジャーナル・号・ページ	Eur J Med Chem, Vol. 155, Page 337-352, Year 2018
掲載日	2017年1月18日 (構造データの登録日)
著者	Zhu, J. / Zhou, C. / Caflisch, A.
リンク	Eur J Med Chem / PubMed:29902720
手法	X線回折
解像度	1.25 - 1.95 Å
構造データ	PDB-5mwg: Crystal structure of the human BRPF1 bromodomain in complex with BZ091 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-5mwh: Crystal structure of the human BRPF1 bromodomain in complex with BZ089 手法: X-RAY DIFFRACTION / 解像度: 1.65 Å PDB-5mwz: Crystal structure of the human BRPF1 bromodomain in complex with BZ073 手法: X-RAY DIFFRACTION / 解像度: 1.25 Å PDB-5o4s: Crystal structure of the human BRPF1 bromodomain in complex with BZ135 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-5o4t: Crystal structure of the human BRPF1 bromodomain in complex with BZ061 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-5o55: Crystal structure of the human BRPF1 bromodomain in complex with BZ047 手法: X-RAY DIFFRACTION / 解像度: 1.45 Å PDB-5o5a: Crystal structure of the human BRPF1 bromodomain in complex with BZ032 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-5o5f: Crystal structure of the human BRPF1 bromodomain in complex with BZ038 手法: X-RAY DIFFRACTION / 解像度: 1.302 Å PDB-5o5h: Crystal structure of the human BRPF1 bromodomain in complex with BZ053 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-5ov8: Crystal structure of the human BRPF1 bromodomain in complex with BZ097 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-5owa: Crystal structure of the human BRPF1 bromodomain in complex with BZ054 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-6ekq: Crystal structure of the human BRPF1 bromodomain complexed with BZ054 in space group C2 手法: X-RAY DIFFRACTION / 解像度: 1.65 Å
化合物	ChemComp-WGX: ~{N}-[1,4-dimethyl-2,3-bis(oxidanylidene)-7-piperidin-1-yl-quinoxalin-6-yl]-5,6,7,8-tetrahydronaphthalene-2-sulfonamide ChemComp-NO3: NITRATE ION / 硝酸塩 ChemComp-HOH: WATER / 水 ChemComp-UWX: ~{N}-[1,4-dimethyl-7-morpholin-4-yl-2,3-bis(oxidanylidene)quinoxalin-6-yl]-4-(2-methylpropyl)benzenesulfonamide ChemComp-KGU: ~{N}-[1,4-diethyl-2,3-bis(oxidanylidene)-7-piperidin-1-yl-quinoxalin-6-yl]-2-(4-methylpiperazin-1-yl)ethanamide ChemComp-9KW: ~{N}-[1,4-dimethyl-7-morpholin-4-yl-2,3-bis(oxidanylidene)quinoxalin-6-yl]-5,6,7,8-tetrahydronaphthalene-2-sulfonamide ChemComp-9KT: 1,4-dimethylquinoxaline-2,3-dione / 1,4-ジヒドロ-1,4-ジメチル-2,3-キノキサリンジオン ChemComp-9L5: ~{N}-[(1~{S})-1-(1,5-dimethylpyrazol-4-yl)ethyl]-1-ethyl-3-methyl-2-oxidanylidene-quinoxaline-6-carboxamide ChemComp-9LN: 1-ethyl-~{N}-methyl-2,3-bis(oxidanylidene)-~{N}-[(1-phenylpyrazol-4-yl)methyl]-4~{H}-quinoxaline-6-carboxamide ChemComp-9LT: 1-ethyl-~{N}-[(~{R})-(3-fluorophenyl)-(1-methylimidazol-2-yl)methyl]-2,3-bis(oxidanylidene)-4~{H}-quinoxaline-6-carboxamide ChemComp-9LK: ~{N}-[6-(4-chloranylphenoxy)pyridin-3-yl]-2,4-dimethyl-1,3-oxazole-5-carboxamide ChemComp-AXN: ~{N}-[1,4-dimethyl-2,3-bis(oxidanylidene)-7-pyrrolidin-1-yl-quinoxalin-6-yl]-4-(2-methylpropyl)benzenesulfonamide ChemComp-B0H: ~{N}-[4-[[(3~{S},5~{R})-3,5-dimethylpiperidin-1-yl]methyl]-1,3-thiazol-2-yl]-2,4-dimethyl-1,3-oxazole-5-carboxamide
由来	homo sapiens (ヒト)
キーワード	DNA BINDING PROTEIN (DNA結合タンパク質) / Bromodomain and PHD finger-containing protein 1(BRPF1) / monocytic leukemia zinc-finger (MOZ) / Inhibitor / transcription (転写 (生物学))