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-Structure paper
Title | Crystal structure of human Caspase-1 with 2-((2-naphthoyl)-L-valyl)-4-hydroxy-N-((3S)-2-hydroxy-5-oxotetrahydrofuran-3-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide (Compound 1) |
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Journal, issue, pages | To Be Published |
Publish date | Dec 12, 2016 (structure data deposition date) |
![]() | Brethon, A. / Chantalat, L. / Christin, O. / Clary, L. / Fournier, J.F. / Gastreich, M. / Harris, C. / Pascau, J. / Isabet, T. / Rodeschin, V. ...Brethon, A. / Chantalat, L. / Christin, O. / Clary, L. / Fournier, J.F. / Gastreich, M. / Harris, C. / Pascau, J. / Isabet, T. / Rodeschin, V. / Thoreau, E. / Roche, D. |
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Methods | X-ray diffraction |
Resolution | 2.15 Å |
Structure data | ![]() PDB-5mmv: |
Chemicals | ![]() ChemComp-WE0: ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE / caspase-1 / nanomolar inhibitor / inflammatory diseases / sp3 hybridization |