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Structure paper

TitleStructural Basis Of Il-23 Antagonism By An Alphabody Protein Scaffold.
Journal, issue, pagesNat Commun, Vol. 5, Page 5237-, Year 2014
Publish dateNov 29, 2016 (structure data deposition date)
AuthorsDesmet, J. / Verstraete, K. / Bloch, Y. / Lorent, E. / Wen, Y. / Devreese, B. / Vandenbroucke, K. / Loverix, S. / Hettmann, T. / Deroo, S. ...Desmet, J. / Verstraete, K. / Bloch, Y. / Lorent, E. / Wen, Y. / Devreese, B. / Vandenbroucke, K. / Loverix, S. / Hettmann, T. / Deroo, S. / Somers, K. / Henderikx, P. / Lasters, I. / Savvides, S.N.
External linksNat Commun / PubMed:25354530
MethodsX-ray diffraction
Resolution1.74 - 3.4 Å
Structure data

PDB-5mj3:
INTERLEUKIN-23 COMPLEX WITH AN ANTAGONISTIC ALPHABODY, CRYSTAL FORM 1
Method: X-RAY DIFFRACTION / Resolution: 1.74 Å

PDB-5mj4:
INTERLEUKIN-23 COMPLEX WITH AN ANTAGONISTIC ALPHABODY, CRYSTAL FORM 2
Method: X-RAY DIFFRACTION / Resolution: 3.4 Å

Chemicals

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsIMMUNE SYSTEM / DESIGNED ANTIPARALLEL TRIPLE-HELIX COILED-COIL / ALPHABODY / IMMUNOGLOBULIN DOMAIN / 4-HELICAL BUNDLE CYTOKINE / ANTAGONIST / N-LINKED GLYCOSYLATION / ALKYLATION / SINGLE-CHAIN ANTIPARALLEL TRIPLE-HELIX COILED-COIL / IMMUNOGLOBULIN-LIKE / 4-ALPHA HELICAL BUNDLE / CYTOKINE-ANTAGONIST COMPLEX

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