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TitleTargeting Endoplasmic Reticulum alpha-Glucosidase I with a Single-Dose Iminosugar Treatment Protects against Lethal Influenza and Dengue Virus Infections.
Journal, issue, pagesJ. Med. Chem., Year 2020
Publish dateNov 24, 2016 (structure data deposition date)
AuthorsWarfield, K.L. / Alonzi, D.S. / Hill, J.C. / Caputo, A.T. / Roversi, P. / Kiappes, J.L. / Sheets, N. / Duchars, M. / Dwek, R.A. / Biggins, J. ...Warfield, K.L. / Alonzi, D.S. / Hill, J.C. / Caputo, A.T. / Roversi, P. / Kiappes, J.L. / Sheets, N. / Duchars, M. / Dwek, R.A. / Biggins, J. / Barnard, D. / Shresta, S. / Treston, A.M. / Zitzmann, N.
External linksJ. Med. Chem. / PubMed:32227946
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-5mhf:
Murine endoplasmic reticulum alpha-glucosidase I with N-9'-methoxynonyl-1-deoxynojirimycin.
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-6A9:
N-9'-methoxynonyl-1-deoxynojirimycin

ChemComp-7PG:
2,5,8,11,14,17,20,23-OCTAOXAPENTACOSAN-25-OL

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
KeywordsHYDROLASE / GH63 / Glucosidase / Iminosugar

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