Database of articles cited by EMDB/PDB/SASBDB data

Keywords
Structure methods	All X-ray diffraction NMR electron microscopy small angle scattering neutron diffraction fiber diffraction powder diffraction infrared spectroscopy EPR fluorescence transfer theoretical model Hybrid
Author
Journal
IF	>30 >20 >10 >5 all

Title	The target landscape of clinical kinase drugs.
Journal, issue, pages	Science, Vol. 358, Year 2017
Publish date	Jun 17, 2016 (structure data deposition date)
Authors	Klaeger, S. / Heinzlmeir, S. / Wilhelm, M. / Polzer, H. / Vick, B. / Koenig, P.A. / Reinecke, M. / Ruprecht, B. / Petzoldt, S. / Meng, C. ...Klaeger, S. / Heinzlmeir, S. / Wilhelm, M. / Polzer, H. / Vick, B. / Koenig, P.A. / Reinecke, M. / Ruprecht, B. / Petzoldt, S. / Meng, C. / Zecha, J. / Reiter, K. / Qiao, H. / Helm, D. / Koch, H. / Schoof, M. / Canevari, G. / Casale, E. / Depaolini, S.R. / Feuchtinger, A. / Wu, Z. / Schmidt, T. / Rueckert, L. / Becker, W. / Huenges, J. / Garz, A.K. / Gohlke, B.O. / Zolg, D.P. / Kayser, G. / Vooder, T. / Preissner, R. / Hahne, H. / Tonisson, N. / Kramer, K. / Gotze, K. / Bassermann, F. / Schlegl, J. / Ehrlich, H.C. / Aiche, S. / Walch, A. / Greif, P.A. / Schneider, S. / Felder, E.R. / Ruland, J. / Medard, G. / Jeremias, I. / Spiekermann, K. / Kuster, B.
External links	Science / PubMed:29191878
Methods	X-ray diffraction
Resolution	1.4 - 2.8 Å
Structure data	PDB-5lbw: Structure of the human quinone reductase 2 (NQO2) in complex with volitinib Method: X-RAY DIFFRACTION / Resolution: 1.9 Å PDB-5lby: Structure of the human quinone reductase 2 (NQO2) in complex with crenolanib Method: X-RAY DIFFRACTION / Resolution: 1.4 Å PDB-5lbz: Structure of the human quinone reductase 2 (NQO2) in complex with pacritinib Method: X-RAY DIFFRACTION / Resolution: 1.4 Å PDB-5m5a: Crystal structure of MELK in complex with an inhibitor Method: X-RAY DIFFRACTION / Resolution: 1.9 Å PDB-5maf: Crystal structure of MELK in complex with an inhibitor Method: X-RAY DIFFRACTION / Resolution: 2.8 Å PDB-5mag: Crystal structure of MELK in complex with an inhibitor Method: X-RAY DIFFRACTION / Resolution: 2.35 Å PDB-5mah: Crystal structure of MELK in complex with an inhibitor Method: X-RAY DIFFRACTION / Resolution: 2 Å PDB-5mai: Crystal structure of MELK in complex with an inhibitor Method: X-RAY DIFFRACTION / Resolution: 2.15 Å
Chemicals	ChemComp-ZN: Unknown entry ChemComp-FAD: FLAVIN-ADENINE DINUCLEOTIDE / FADYM ChemComp-V0L: volitinib / inhibitorYM ChemComp-HOH: WATER ChemComp-6T2: 1-(2-{5-[(3-Methyloxetan-3-yl)methoxy]-1H-benzimidazol-1-yl}quinolin-8-yl)piperidin-4-amine ChemComp-6T3: 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene ChemComp-SO4: SULFATE ION ChemComp-NA: Unknown entry ChemComp-CL: Unknown entry ChemComp-KSA: K-252A ChemComp-DMS: DIMETHYL SULFOXIDE / DMSO, precipitantYM ChemComp-XIN: methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate / medicationYM ChemComp-7KC: PF-3758309 ChemComp-GOL: GLYCEROL ChemComp-7KD: ~{N}-methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide ChemComp-5U5: 3-[(3~{Z})-3-[[[4-[(dimethylamino)methyl]phenyl]amino]-phenyl-methylidene]-2-oxidanylidene-1~{H}-indol-6-yl]-~{N}-ethyl-prop-2-ynamide
Source	homo sapiens (human)
Keywords	OXIDOREDUCTASE / quinone reductase 2 / kinase inhibitor / volitinib / Ribosyldihydronicotinamide dehydrogenase / crenolanib / pancritinib / Ribosyldihydronicotinamide dehydrogenase (NQO2) / TRANSFERASE / kinase / inhibitor / complex