| タイトル | Structural and functional insight into human O-GlcNAcase. |
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| ジャーナル・号・ページ | Nat. Chem. Biol., Vol. 13, Page 610-612, Year 2017 |
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| 掲載日 | 2016年10月28日 (構造データの登録日) |
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著者 | Roth, C. / Chan, S. / Offen, W.A. / Hemsworth, G.R. / Willems, L.I. / King, D.T. / Varghese, V. / Britton, R. / Vocadlo, D.J. / Davies, G.J. |
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リンク | Nat. Chem. Biol. / PubMed:28346405 |
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| 手法 | X線回折 |
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| 解像度 | 2.3 - 2.6 Å |
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| 構造データ | PDB-5m7r: Structure of human O-GlcNAc hydrolase 手法: X-RAY DIFFRACTION / 解像度: 2.35 Å PDB-5m7s: Structure of human O-GlcNAc hydrolase with bound transition state analog ThiametG 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-5m7t: Structure of human O-GlcNAc hydrolase with PugNAc type inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-5m7u: Structure of human O-GlcNAc hydrolase with new iminocyclitol type inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å |
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| 化合物 | ChemComp-NHT: (3AR,5R,6S,7R,7AR)-2-(ETHYLAMINO)-5-(HYDROXYMETHYL)-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D][1,3]THIAZOLE-6,7-DIOL / 1,2-(チオ(1-(エチルアミノ)メチリジンニトリロ))-1,2-ジデオキシ-α-D-グルコピラノ-ス
ChemComp-GDV: (5R,6R,7R,8S)-8-(ACETYLAMINO)-6,7-DIHYDROXY-5-(HYDROXYMETHYL)-N-PHENYL-1,5,6,7,8,8A-HEXAHYDROIMIDAZO[1,2-A]PYRIDINE-2-CARBOXAMIDE
ChemComp-XHA: 2-[(2~{R},3~{S},4~{R},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)-1-[3-[3-(trifluoromethyl)phenyl]propyl]pyrrolidin-2-yl]-~{N}-methyl-ethanamide
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| 由来 | homo sapiens (ヒト)
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キーワード | HYDROLASE / human glacoside hydrolase GlcNAc / hOGA O-GlcNAc / human glacoside hydrolase / GlcNAc / human glycoside hydrolase |
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