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-Structure paper
Title | Highly selective inhibition of histone demethylases by de novo macrocyclic peptides. |
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Journal, issue, pages | Nat Commun, Vol. 8, Page 14773-14773, Year 2017 |
Publish date | Sep 23, 2016 (structure data deposition date) |
![]() | Kawamura, A. / Munzel, M. / Kojima, T. / Yapp, C. / Bhushan, B. / Goto, Y. / Tumber, A. / Katoh, T. / King, O.N. / Passioura, T. ...Kawamura, A. / Munzel, M. / Kojima, T. / Yapp, C. / Bhushan, B. / Goto, Y. / Tumber, A. / Katoh, T. / King, O.N. / Passioura, T. / Walport, L.J. / Hatch, S.B. / Madden, S. / Muller, S. / Brennan, P.E. / Chowdhury, R. / Hopkinson, R.J. / Suga, H. / Schofield, C.J. |
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Methods | X-ray diffraction |
Resolution | 2.43 - 2.5 Å |
Structure data | ![]() PDB-5ly1: ![]() PDB-5ly2: |
Chemicals | ![]() ChemComp-NI: ![]() ChemComp-ZN: ![]() ChemComp-CL: ![]() ChemComp-GOL: ![]() ChemComp-PPI: ![]() ChemComp-HOH: ![]() ChemComp-OGA: |
Source |
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![]() | OXIDOREDUCTASE / JMJD2A / KDM4A / NON-HEME / IRON / 2-OXOGLUTARATE / DIOXYGENASE / OXYGENASE / DOUBLE-STRANDED BETA HELIX / DSBH / FACIAL TRIAD / DEMETHYLASE / HISTONE / JMJC DOMAIN / METAL BINDING PROTEIN / EPIGENETIC AND TRANSCRIPTION REGULATION / CHROMATIN REGULATOR / HYDROXYLATION |