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TitleBetulinic acid is a PPAR gamma antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis.
Journal, issue, pagesSci Rep, Vol. 7, Page 5777-5777, Year 2017
Publish dateAug 26, 2016 (structure data deposition date)
AuthorsBrusotti, G. / Montanari, R. / Capelli, D. / Cattaneo, G. / Laghezza, A. / Tortorella, P. / Loiodice, F. / Peiretti, F. / Bonardo, B. / Paiardini, A. ...Brusotti, G. / Montanari, R. / Capelli, D. / Cattaneo, G. / Laghezza, A. / Tortorella, P. / Loiodice, F. / Peiretti, F. / Bonardo, B. / Paiardini, A. / Calleri, E. / Pochetti, G.
External linksSci Rep / PubMed:28720829
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-5lsg:
PPARgamma complex with the betulinic acid
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-QZQ:
Betulinic Acid / anticancer, antiinflammatory, antiretroviral*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / Antagonist / Complex / Transcription Factor / Nuclear Receptor

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