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TitleThe Mechanism of Regulation of Pantothenate Biosynthesis by the PanD-PanZAcCoA Complex Reveals an Additional Mode of Action for the Antimetabolite N-Pentyl Pantothenamide (N5-Pan).
Journal, issue, pagesBiochemistry, Vol. 56, Page 4931-4939, Year 2017
Publish dateAug 22, 2016 (structure data deposition date)
AuthorsArnott, Z.L.P. / Nozaki, S. / Monteiro, D.C.F. / Morgan, H.E. / Pearson, A.R. / Niki, H. / Webb, M.E.
External linksBiochemistry / PubMed:28832133
MethodsX-ray diffraction
Resolution1.16 Å
Structure data

PDB-5ls7:
Complex of wild type E. coli alpha aspartate decarboxylase with its processing factor PanZ
Method: X-RAY DIFFRACTION / Resolution: 1.16 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-ACO:
ACETYL COENZYME *A

ChemComp-MG:
Unknown entry

ChemComp-CO2:
CARBON DIOXIDE

ChemComp-SCN:
THIOCYANATE ION

ChemComp-74C:
methyl radical

ChemComp-HOH:
WATER

Source
  • escherichia coli k-12 (bacteria)
KeywordsLYASE / protein derived cofactor / coenzyme A biosynthesis / protein complex / metabolic pathway regulation

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