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Title2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 113, Page E5271-E5280, Year 2016
Publish dateJun 14, 2016 (structure data deposition date)
AuthorsBauer, M.R. / Joerger, A.C. / Fersht, A.R.
External linksProc. Natl. Acad. Sci. USA / PubMed:27551077
MethodsX-ray diffraction
Resolution1.42 Å
Structure data

PDB-5lap:
p53 cancer mutant Y220C with Cys182 alkylation
Method: X-RAY DIFFRACTION / Resolution: 1.42 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-6SM:
5-chloranylpyrimidine-4-carboxylic acid

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsDNA BINDING PROTEIN / p53 / tumor suppressor / cancer mutation / protein stabilization / alkylating agents / 2-sulfonylpyrimidines / cancer therapy

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