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-Structure paper
Title | Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 26, Page 5044-5050, Year 2016 |
Publish date | Jul 21, 2016 (structure data deposition date) |
Authors | Tice, C.M. / Noto, P.B. / Fan, K.Y. / Zhao, W. / Lotesta, S.D. / Dong, C. / Marcus, A.P. / Zheng, Y.J. / Chen, G. / Wu, Z. ...Tice, C.M. / Noto, P.B. / Fan, K.Y. / Zhao, W. / Lotesta, S.D. / Dong, C. / Marcus, A.P. / Zheng, Y.J. / Chen, G. / Wu, Z. / Van Orden, R. / Zhou, J. / Bukhtiyarov, Y. / Zhao, Y. / Lipinski, K. / Howard, L. / Guo, J. / Kandpal, G. / Meng, S. / Hardy, A. / Krosky, P. / Gregg, R.E. / Leftheris, K. / McKeever, B.M. / Singh, S.B. / Lala, D. / McGeehan, G.M. / Zhuang, L. / Claremon, D.A. |
External links | Bioorg. Med. Chem. Lett. / PubMed:27599745 |
Methods | X-ray diffraction |
Resolution | 2.598 - 2.8 Å |
Structure data | PDB-5kya: PDB-5kyj: |
Chemicals | ChemComp-6Y4: ChemComp-HOH: ChemComp-6Y8: |
Source |
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Keywords | DNA BINDING PROTEIN / Nuclear receptor / Liver X Receptor / LXRbeta-LBD/RXRbeta-LBD heterodimer / Chemical modulators / Nuclear receptors / Retinoic Acid X Receptor |