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-Structure paper
Title | Efforts towards the optimization of a bi-aryl class of potent IRAK4 inhibitors. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 26, Page 4250-4255, Year 2016 |
Publish date | Jul 20, 2016 (structure data deposition date) |
Authors | Hanisak, J. / Seganish, W.M. / McElroy, W.T. / Tang, H. / Zhang, R. / Tsui, H.C. / Fischmann, T. / Tulshian, D. / Tata, J. / Sondey, C. ...Hanisak, J. / Seganish, W.M. / McElroy, W.T. / Tang, H. / Zhang, R. / Tsui, H.C. / Fischmann, T. / Tulshian, D. / Tata, J. / Sondey, C. / Devito, K. / Fossetta, J. / Garlisi, C.G. / Lundell, D. / Niu, X. |
External links | Bioorg. Med. Chem. Lett. / PubMed:27476420 |
Methods | X-ray diffraction |
Resolution | 2.671 - 2.8 Å |
Structure data | PDB-5kx7: PDB-5kx8: |
Chemicals | ChemComp-6YD: ChemComp-6YE: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE/TRANSFERASE inhibitor / KINASE / PHOSPHATASE / TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX |