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-Structure paper
Title | Discovery of S3-Truncated, C-6 Heteroaryl Substituted Aminothiazine beta-Site APP Cleaving Enzyme-1 (BACE1) Inhibitors. |
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Journal, issue, pages | J. Med. Chem., Vol. 59, Page 8593-8600, Year 2016 |
Publish date | Jul 6, 2016 (structure data deposition date) |
Authors | Wu, Y.J. / Guernon, J. / Shi, J. / Marcin, L. / Higgins, M. / Rajamani, R. / Muckelbauer, J. / Lewis, H. / Chang, C. / Camac, D. ...Wu, Y.J. / Guernon, J. / Shi, J. / Marcin, L. / Higgins, M. / Rajamani, R. / Muckelbauer, J. / Lewis, H. / Chang, C. / Camac, D. / Toyn, J.H. / Ahlijanian, M.K. / Albright, C.F. / Macor, J.E. / Thompson, L.A. |
External links | J. Med. Chem. / PubMed:27559936 |
Methods | X-ray diffraction |
Resolution | 1.98 - 2.118 Å |
Structure data | PDB-5kqf: PDB-5kr8: |
Chemicals | ChemComp-6WD: ChemComp-HOH: ChemComp-IOD: ChemComp-6WE: |
Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / BACE-1 / small molecule inhibitor / HYDROLASE-HYDROLASE INHIBITOR complex |