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Title | Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity. |
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Journal, issue, pages | J. Biol. Chem., Vol. 292, Page 446-461, Year 2017 |
Publish date | Jun 29, 2016 (structure data deposition date) |
![]() | Esser, L. / Zhou, F. / Pluchino, K.M. / Shiloach, J. / Ma, J. / Tang, W.K. / Gutierrez, C. / Zhang, A. / Shukla, S. / Madigan, J.P. ...Esser, L. / Zhou, F. / Pluchino, K.M. / Shiloach, J. / Ma, J. / Tang, W.K. / Gutierrez, C. / Zhang, A. / Shukla, S. / Madigan, J.P. / Zhou, T. / Kwong, P.D. / Ambudkar, S.V. / Gottesman, M.M. / Xia, D. |
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Methods | X-ray diffraction |
Resolution | 3.3 - 4.01 Å |
Structure data | ![]() PDB-5ko2: ![]() PDB-5koy: ![]() PDB-5kpd: ![]() PDB-5kpi: ![]() PDB-5kpj: |
Chemicals | ![]() ChemComp-HG: ![]() ChemComp-ATP: ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE / Mouse pgp / multidrug resistance / drug transport / Mercury derivative / ATP bound / ABC transporter / membrane protein / drug efflux / native / methylated protein |