+Search query
-Structure paper
Title | Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity. |
---|---|
Journal, issue, pages | J. Biol. Chem., Vol. 292, Page 446-461, Year 2017 |
Publish date | Jun 29, 2016 (structure data deposition date) |
Authors | Esser, L. / Zhou, F. / Pluchino, K.M. / Shiloach, J. / Ma, J. / Tang, W.K. / Gutierrez, C. / Zhang, A. / Shukla, S. / Madigan, J.P. ...Esser, L. / Zhou, F. / Pluchino, K.M. / Shiloach, J. / Ma, J. / Tang, W.K. / Gutierrez, C. / Zhang, A. / Shukla, S. / Madigan, J.P. / Zhou, T. / Kwong, P.D. / Ambudkar, S.V. / Gottesman, M.M. / Xia, D. |
External links | J. Biol. Chem. / PubMed:27864369 |
Methods | X-ray diffraction |
Resolution | 3.3 - 4.01 Å |
Structure data | PDB-5ko2: PDB-5koy: PDB-5kpd: PDB-5kpi: PDB-5kpj: |
Chemicals | ChemComp-HG: ChemComp-ATP: ChemComp-HOH: |
Source |
|
Keywords | HYDROLASE / Mouse pgp / multidrug resistance / drug transport / Mercury derivative / ATP bound / ABC transporter / membrane protein / drug efflux / native / methylated protein |