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Structure paper

TitleIterative structure-based improvement of a fusion-glycoprotein vaccine against RSV.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 23, Page 811-820, Year 2016
Publish dateMay 24, 2016 (structure data deposition date)
AuthorsJoyce, M.G. / Zhang, B. / Ou, L. / Chen, M. / Chuang, G.Y. / Druz, A. / Kong, W.P. / Lai, Y.T. / Rundlet, E.J. / Tsybovsky, Y. ...Joyce, M.G. / Zhang, B. / Ou, L. / Chen, M. / Chuang, G.Y. / Druz, A. / Kong, W.P. / Lai, Y.T. / Rundlet, E.J. / Tsybovsky, Y. / Yang, Y. / Georgiev, I.S. / Guttman, M. / Lees, C.R. / Pancera, M. / Sastry, M. / Soto, C. / Stewart-Jones, G.B. / Thomas, P.V. / Van Galen, J.G. / Baxa, U. / Lee, K.K. / Mascola, J.R. / Graham, B.S. / Kwong, P.D.
External linksNat. Struct. Mol. Biol. / PubMed:27478931
MethodsX-ray diffraction
Resolution2.59 - 3.576 Å
Structure data

PDB-5k6b:
Crystal structure of prefusion-stabilized RSV F single-chain 9 DS-Cav1 variant.
Method: X-RAY DIFFRACTION / Resolution: 2.981 Å

PDB-5k6c:
Crystal structure of prefusion-stabilized RSV F single-chain 9-10 DS-Cav1 variant.
Method: X-RAY DIFFRACTION / Resolution: 3.576 Å

PDB-5k6f:
Crystal structure of prefusion-stabilized RSV F single-chain 9-19 DS-Cav1 variant.
Method: X-RAY DIFFRACTION / Resolution: 2.59 Å

PDB-5k6g:
Crystal structure of prefusion-stabilized RSV F single-chain 9-24 DS-Cav1 variant.
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-5k6h:
Crystal structure of prefusion-stabilized RSV F single-chain 9-10 DS-Cav1 A149C-Y458C variant.
Method: X-RAY DIFFRACTION / Resolution: 2.648 Å

PDB-5k6i:
Crystal structure of prefusion-stabilized RSV F single-chain 9-10 DS-Cav1 A149C-Y458C, S46G-E92D-S215P-K465Q variant.
Method: X-RAY DIFFRACTION / Resolution: 2.92 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-ZN:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-PO4:
PHOSPHATE ION

Source
  • human respiratory syncytial virus a
  • human respiratory syncytial virus a (strain a2)
KeywordsVIRAL PROTEIN / Respiratory Syncytial Virus / Prefusion / Vaccine / Stabilized

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