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-Structure paper
| Title | Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis. |
|---|---|
| Journal, issue, pages | ACS Infect Dis, Vol. 3, Page 18-33, Year 2017 |
| Publish date | May 22, 2016 (structure data deposition date) |
 Authors | Park, Y. / Pacitto, A. / Bayliss, T. / Cleghorn, L.A. / Wang, Z. / Hartman, T. / Arora, K. / Ioerger, T.R. / Sacchettini, J. / Rizzi, M. ...Park, Y. / Pacitto, A. / Bayliss, T. / Cleghorn, L.A. / Wang, Z. / Hartman, T. / Arora, K. / Ioerger, T.R. / Sacchettini, J. / Rizzi, M. / Donini, S. / Blundell, T.L. / Ascher, D.B. / Rhee, K. / Breda, A. / Zhou, N. / Dartois, V. / Jonnala, S.R. / Via, L.E. / Mizrahi, V. / Epemolu, O. / Stojanovski, L. / Simeons, F. / Osuna-Cabello, M. / Ellis, L. / MacKenzie, C.J. / Smith, A.R. / Davis, S.H. / Murugesan, D. / Buchanan, K.I. / Turner, P.A. / Huggett, M. / Zuccotto, F. / Rebollo-Lopez, M.J. / Lafuente-Monasterio, M.J. / Sanz, O. / Diaz, G.S. / Lelievre, J. / Ballell, L. / Selenski, C. / Axtman, M. / Ghidelli-Disse, S. / Pflaumer, H. / Bosche, M. / Drewes, G. / Freiberg, G.M. / Kurnick, M.D. / Srikumaran, M. / Kempf, D.J. / Green, S.R. / Ray, P.C. / Read, K. / Wyatt, P. / Barry, C.E. / Boshoff, H.I. |
 External links | ACS Infect Dis / PubMed:27704782 |
| Methods | X-ray diffraction |
| Resolution | 1.37 - 1.64 Å |
| Structure data |  PDB-5k4x:  PDB-5k4z: |
| Chemicals |  ChemComp-6Q9:  ChemComp-IMP:  ChemComp-HOH:  ChemComp-6Q8: |
| Source |
|
 Keywords | OXIDOREDUCTASE / IMPDH / GuaB2 / inhibitor-complex |
mycobacterium thermoresistibile (bacteria)